# Testosterone enanthate vs cypionate: what is different

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**Sources checked:** 2026-11-06
**Publisher:** Open Water RX LLC

By Open Water Rx Editorial Team. Published November 6, 2026. Sources checked November 6, 2026.

## Short answer

Testosterone enanthate and testosterone cypionate are two long-acting forms (esters) of the same hormone, testosterone. Both are injected and both labels give 50 to 400 mg every 2 to 4 weeks for men with low testosterone. The practical differences are the product: cypionate (Depo-Testosterone and generics) comes in 100 mg/ml and 200 mg/ml vials in cottonseed oil, while enanthate comes as a 200 mg/ml vial in sesame oil and as the Xyosted weekly autoinjector. The Endocrine Society lists the same typical starting doses for both.

## Side by side

| Comparison point | Testosterone cypionate | Testosterone enanthate |
| --- | --- | --- |
| Brands | Depo-Testosterone, generics | Generic vials; Xyosted autoinjector |
| Strengths | 100 mg/ml and 200 mg/ml vials | 200 mg/ml vial; Xyosted 50, 75, 100 mg |
| Oil | Cottonseed oil | Sesame oil (vial) |
| Where injected | Deep in the gluteal muscle | Vial: gluteal muscle. Xyosted: under the skin of the abdomen |
| Label dose | 50 to 400 mg every 2 to 4 weeks | Vial: 50 to 400 mg every 2 to 4 weeks. Xyosted: weekly, starting at 75 mg |
| Endocrine Society typical start | 75 to 100 mg weekly, or 150 to 200 mg every 2 weeks | Same |
| Storage | Room temperature, protect from light | Room temperature |

## Which one to choose

The choice usually comes down to what your prescriber uses, which strengths and devices are available, the oil (for anyone with a sesame or cottonseed allergy), and price. Dose and schedule are set by your prescriber from blood tests.

## What it costs online

This guide records what each program charges on its own page, with the date the figure was read. The 9 programs that publish a monthly figure charge from $28 to $250 a month on known charges, with a median of $149. The lowest verified all-in figure is $199 a month. Those records were read between October 23 and October 26, 2026, and each one carries its own check date.

See also:
- How much does testosterone therapy cost: https://trtbuyerguide.com/how-much-does-testosterone-therapy-cost
- Depo-Testosterone: https://trtbuyerguide.com/medications/depo-testosterone
- Xyosted: https://trtbuyerguide.com/medications/xyosted

## Frequently asked questions

### Is testosterone enanthate stronger than cypionate?

No. Both are long-acting forms of testosterone, and their labels give the same dose range of 50 to 400 mg every 2 to 4 weeks.

### What is the difference between testosterone cypionate and enanthate?

They are different esters of testosterone sold as different products. Cypionate comes in 100 and 200 mg/ml vials in cottonseed oil; enanthate comes as a 200 mg/ml vial in sesame oil and as the Xyosted autoinjector.

### Can you switch from cypionate to enanthate?

Only your prescriber should switch products or change doses, based on your blood tests.

### Which one is more common?

Cypionate is widely prescribed in the United States as Depo-Testosterone and its generics. Ask your prescriber which product your plan uses.

## Sources

- [Depo-Testosterone prescribing information, DailyMed](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cfbb53d4-b868-4a28-8436-f9112eb01c39)
- [Testosterone enanthate injection prescribing information, DailyMed](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=82a98132-9d5f-40a5-8c4f-f52f2a5de60e)
- [Xyosted prescribing information, DailyMed](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a3d204c-be26-49e0-8599-0ac12a272e81)
- [Endocrine Society, Testosterone Therapy in Men With Hypogonadism (2018)](https://academic.oup.com/jcem/article/103/5/1715/4939465)

## Related

- Testosterone enanthate: https://trtbuyerguide.com/learn/testosterone-enanthate
- Is 1 ml of testosterone a week enough?: https://trtbuyerguide.com/learn/is-1-ml-of-testosterone-a-week-enough

## Publisher

Open Water RX LLC publishes this guide, GLP1BuyerGuide.com and HRTBuyerGuide.com, and operates Surfbound Health, a consumer telehealth brand. Surfbound Health is not a provider in this edition and takes no part in its ranking.

This page summarizes published prescribing information and medical references on the dates shown. It is not medical advice and does not recommend a treatment.